Oxidative Stress Mediates the Fetal Programming of Hypertension by Glucocorticoids

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Glucocorticoids and fetal programming.

Glucocorticoids Glucocorticoid hormones (cortisol in humans and most mammals, corticosterone in rats, mice and most lower vertebrates) are produced by the adrenal glands, predominantly under the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Receptors for glucocorticoids are members of the nuclear hormone receptor superfamily and, when activated by their hormone ligands, regulate ...

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Impact of Oxidative Stress in Fetal Programming

Intrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under- and overnutrition, and excessive glucocorticoid exposure. The role of oxidant molecules as signaling factors in fetal programming via epigenetic mechanisms is discussed. By linking oxidative stress w...

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Maternal glucocorticoids and prenatal programming of hypertension.

Maternal glucocorticoids have been postulated to play an important role in prenatal programming for adult hypertension in the offspring. However, we have shown previously that offspring hypertension caused by maternal dexamethasone subcutaneous administration at 100 microg x kg(-1) x day(-1) can be accounted for by the corresponding reduction in food intake that these mothers experience. The pr...

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Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension.

BACKGROUND Obesity is one of the major risk factors for cardiovascular disease and is often associated with increased oxidative stress and sympathoexcitation. We have already suggested that increased oxidative stress in the brain modulates the sympathetic regulation of arterial pressure in salt-sensitive hypertension, which is often associated with obesity. The present study was performed to de...

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Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in salt-sensitive hypertension.

Central sympathoexcitation is involved in the pathogenesis of salt-sensitive hypertension. We have suggested that oxidative stress in the brain modulates the sympathetic regulation of arterial pressure. Thus, we investigated whether oxidative stress could mediate central sympathoexcitation in salt-sensitive hypertension. Five- to 6-week-old male Dahl salt-sensitive rats and salt-resistant rats ...

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ژورنال

عنوان ژورنال: Antioxidants

سال: 2021

ISSN: 2076-3921

DOI: 10.3390/antiox10040531